1. Isoquinolinone derivatives as potent CNS multi-receptor D 2 /5-HT 1A /5-HT 2A /5-HT 6 /5-HT 7 agents: Synthesis and pharmacological evaluation.
- Author
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Jin J, Zhang K, Dou F, Hao C, Zhang Y, Cao X, Gao L, Xiong J, Liu X, Liu BF, Zhang G, and Chen Y
- Subjects
- Animals, Antipsychotic Agents chemical synthesis, Antipsychotic Agents chemistry, CHO Cells, Cricetulus, Dopamine Agents chemical synthesis, Dopamine Agents chemistry, Drug Design, HEK293 Cells, Humans, Isoquinolines chemical synthesis, Isoquinolines chemistry, Mice, Rats, Sprague-Dawley, Serotonin Agents chemical synthesis, Serotonin Agents chemistry, Structure-Activity Relationship, Antipsychotic Agents pharmacology, Dopamine Agents pharmacology, Isoquinolines pharmacology, Receptors, Dopamine D2 metabolism, Serotonin metabolism, Serotonin Agents pharmacology
- Abstract
In this study, a series of novel Isoquinolinone derivatives were synthesized as potential multi-target antipsychotics. Among these, compound 13 showed high affinity for dopamine D
2 and serotonin 5-HT1A , 5-HT2A , 5-HT6 , and 5-HT7 receptors, showed low affinity for off-target receptors (5-HT2C , H1 , and α1 ), and negligible effects on ether-a-gogo-related gene (hERG; i.e., reduced QT interval prolongation). An animal behavioral study revealed that compound 13 reversed APO-induced hyperlocomotion, MK-801-induced hyperactivity, and DOI-induced head twitch. Moreover, compound 13 exhibited a high threshold for acute toxicity, a lack of tendency to induce catalepsy, and did not cause prolactin secretion or weight gain when compared to risperidone. Furthermore, in the forced swim test, tail suspension test, and novel object recognition test, treatment with compound 13 resulted in improvements in depression and cognitive impairment. In addition, compound 13 had a favorable pharmacokinetic profile in rats. Thus, the antipsychotic drug-like effects of compound 13 indicate that it may be useful for developing a novel class of drugs for the treatment of schizophrenia., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Masson SAS. All rights reserved.)- Published
- 2020
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