1. Effects of Gastrodia Elata Bl on Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice
- Author
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Eun-Joo Shin, J.-H. Jung, Toshitaka Nabeshima, T.-T. L. Nguyen, X.-K. T. Nguyen, M. J. Kim, W. K. Whang, Hyoung-Chun Kim, Kiyofumi Yamada, J.-M. Kim, and S. Y. Lee
- Subjects
Agonist ,medicine.drug_class ,medicine.medical_treatment ,phencyclidine ,Pharmacology ,Serotonergic ,Article ,Medicine ,Pharmacology (medical) ,heterocyclic compounds ,Antipsychotic ,Receptor ,Gastrodia elata Bl ,Phencyclidine ,biology ,business.industry ,5-HT1A receptors ,General Medicine ,Receptor antagonist ,medicine.disease ,biology.organism_classification ,Gastrodia elata ,schizophrenia ,Psychiatry and Mental health ,Neurology ,nervous system ,Schizophrenia ,Neurology (clinical) ,business ,Neuroscience ,medicine.drug - Abstract
It has been demonstrated that 5-HT(1A) receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT(1A) receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT(1A) receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT(1A) in mice.
- Published
- 2011