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In this study, we studied the activity of three antibacterial drugs: Cefotaxime (Claforan, France), Ceftriaxone (Russia) and Doxycycline (Russia). The control group is a pentavalent antimony drug - Glucantim (France), which has been the "gold standard" for a long time in the treatment of any form of leishmaniasis. During the experiments, the leading positions of doxycycline and ceftriaxone established in vitro. Minimal doses of both drugs lead to absolute suppression of the mobility of the pathogen L. major. Increasing the therapeutic dose of drugs is not justified. Comparison of these drugs with the gold standard of therapy with meglumine antimonate (glucantim) showed their superiority in all indicators.