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Koldas, Serkan/0000-0002-7917-4008; OZEN, Tevfik/0000-0003-0133-5630; demirtas, ibrahim/0000-0001-8946-647X WOS: 000349396000018 PubMed: 25200133 BACKGROUNDA detailed phytochemical analysis of Origanum vulgare L. ssp. viride (Boiss.) Hayek was carried out and the antioxidant activities of five different crude extracts were determined. The antiproliferative activities of the extracts were determined using the xCELLigence system (Real Time Cell Analyzer). RESULTSDifferences between the essential oil and volatile organic compound profiles of the plant were shown. The main component of the essential oil was caryophyllene oxide, while the main volatile organic compounds were sabinene and eucalyptol as determined by HS-GC/MS. Phenolic contents of the extracts were determined qualitatively and quantitatively by HPLC/TOF-MS. Ten phenolic compounds were found in the extracts from O. vulgare and Origanum acutidens: rosmarinic acid (in highest abundance), chicoric acid, caffeic acid, p-coumaric acid, gallic acid, quercetin, apigenin-7-glucoside, kaempferol, naringenin and 4-hydroxybenzaldehyde. CONCLUSIONThis study provides first results on the antiproliferative and antioxidant properties and detailed phytochemical screening of O. vulgare ssp. viride (Boiss.) Hayek. (c) 2014 Society of Chemical Industry Cankiri Karatekin University, TurkeyCankiri Karatekin University [BAP 2010/03]; Prime Ministry State Planning Organization [DPT2010K120720] This study was funded by Scientific Research Projects, Cankiri Karatekin University, Turkey (BAP 2010/03) and Prime Ministry State Planning Organization (DPT2010K120720). We also thank Prof. Dr Hamdi Guray Kutbay (Ondokuz Mayis University) for his help in identification of the plant material and Dr Omer Cem Karakoc (Cankiri Karatekin University) for his help with statistical analyses.