Search

Alocasia macrorrhizos (L.) (Araceae), a coarse and erect plant that is widely cultivated to be eaten as a vegetable throughout Bangladesh, has been reported to possess a number of medicinal properties. The antihyperglycemic, antioxidant, and cytotoxic effects of the methanol extract of A. macrorrhizos rhizomes were investigated. The extract was given at a single dose (250 and 500 mg/kg) in alloxan-induced hyperglycemic mice. The extract at 500 mg/kg produced a significant (P < 0.05) decrease in the blood glucose level (55.49%) at 8 h of treatment when compared with the control and was comparable with the reference drug, metformin. The extract was also subjected to antioxidant potentiality and brine shrimp lethality bioassays. The IC50 value of the extract was 693.0 μg/mL and the LC50 was 188.14 μg/mL. [ABSTRACT FROM AUTHOR]

• The antioxidant and thrombolytic potential were evaluated using spectrophotometric and clot lysis methods respectively. • The (1s,15s)bicyclo[13.1.0]hexadecan-2-one compound showed the greatest binding score with 6NGJ (-7.9 kcal/mol) protein. Also, the (1s,15s)bicyclo[13.1.0]hexadecan-2-one compound showed the top binding score with 1A5H (-6.9 kcal/mol) protein. • The ADMET and PASS results depicted that the compounds are non-carcinogenic, have antioxidant, and antiulcerative effects. Corchorus aestuans L. (Malvaceae), a little annual plant, grows in wastelands at low and medium altitudes. It has traditionally been used as an antihistaminic, anti-inflammatory, and antibacterial for chronic cystitis, gonorrhea, and dysuria. Our research aimed to investigate the antioxidant, antimicrobial, and thrombolytic potential of several solvent extracts. Three different solvents were used in the extraction process: methanol, hydro-methanol, and water. Using established qualitative methodologies, phytochemical screening was carried out. Folin-Ciocalteu and aluminum chloride techniques were used to determine the total phenol and flavonoid contents. The antioxidant activity (total antioxidant capacity, DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging, and Fe3+ reducing power) was evaluated using spectrophotometric methods. Besides, clot lysis and disc-diffusion methods were used to assess thrombolytic and antibacterial activity. The GC-MS analysis was also performed to discover prominent phytochemicals. Phytochemical screening revealed the presence of glycosides, alkaloids, flavonoids, phenols, tannins, etc. Among all the extracts, hydro-methanol extract (MACA) possesses the highest total phenol and flavonoid contents (778.2±20.82 mg GAE/g dry extract and 535.44±20.95 mg QE/g dry extract respectively). Similarly, MACA showed the highest total antioxidant capacity (664.31±16.84mg/g equivalent to AA), DPPH scavenging activity (IC 50 : 26.30±2.82 μg/mL), and ferric reducing capacity (EC 50 : 18.58±2.37 μg/mL). Moreover, among the three extracts, MACA showed the highest percentages of clot lysis (40.49 ±1.97 %) and an antibacterial effect against B. subtilis. GC-MS revealed 17 phytoconstituents, whereas (1s,15s) bicyclo [13.1.0] hexadecan-2-one had the greatest binding score with 6NGJ (-7.9 kcal/mol), and 1A5H (-6.9 kcal/mol) proteins. The ADMET studies showed they are non-carcinogenic, and well-absorbed, while PASS prediction and drug-likeness data showed antioxidant, anti-inflammatory, and good oral bioavailability. Therefore, further research will potentiate to discover compounds with antioxidant, thrombolytic, and antibacterial properties, with their mechanism of action. [ABSTRACT FROM AUTHOR]