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Inflammatory diseases including different types of rheumatics are a major cause of morbidity worldwide. This study addresses the global burden of inflammatory diseases, focusing on safer alternatives to synthetic anti-inflammatory drugs. Extracts from ethnomedicinal plants, Delonix elata, Hygrophila auriculata, and Drynaria quercifolia, were combined to enhance their anti-inflammatory properties. The ethanolic extract was obtained from the leaves of Delonix elata, seeds of Hygrophila auriculata, and rhizomes of Drynaria quercifolia, showing the existence of phenolics, flavonoids, and alkaloids in preliminary phytochemical screening. Two combinations, D (1:1:1) and E (10:5:1), were prepared. In vitro studies revealed that combination D shown maximum total antioxidant activity the strongest capacity to scavenge DPPH radicals. Antibacterial assays demonstrated varying zones of inhibition for E. coli and S. aureus among the combinations. Notably, combination D showed the largest zone of inhibition for E. coli, while sample C was most effective against S. aureus. Protein denaturation assay for anti-inflammatory activity highlighted combination D's remarkable inhibition of BSA denaturation (97.37% at 1mg/ml concentration). This research explores potential natural remedies and holistic healthcare solutions through the synergistic effects of plant extracts, aligning with traditional medicinal knowledge. [ABSTRACT FROM AUTHOR]