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The present work describes the synthesis of 6-substituted-3-(1-(4-substituted)-4-((Z)-(5,6-dimethoxy-1-oxo-1H-inden-2(3H)-ylidene)methyl)-1H-pyrazol-3-yl)-2H-chromen-2-one derivatives ( 5a – l ) by Claisen–Schmidt condensation of 3-(6-substituted-2-oxo-2 H -chromen-3-yl)-1-(4-substituted)-1 H -pyrazole-4-carbaldehyde derivatives ( 4a – l ) with 5,6-dimethoxy-2,3-dihydro-1H-inden-1-one at reflux temperature for 8 h. The synthesized compounds were screened for in vitro antioxidant activity. Compounds 5e and 5g showed promising DPPH radical scavenging activity with IC 50 54.14–56.19 μg/mL, ferrous ion chelating ability with IC 50 53.75–56.89 μg/mL and reductive capability with IC 50 58.01–62.57 μg/mL. The selected compounds were also tested for in vivo antihyperglycemic activity against Streptozotocin–nicotinamide induced Adult Wistar rats. Compounds 5e and 5g showed significant decrease in glucose concentration (115 and 138 mg/dL) with the dose of 100 mg/kg. [ABSTRACT FROM AUTHOR]

A convenient one-pot, three-component synthesis of 2, 6-bis (1-coumarin-2-yl)-4-(4-substituted phenyl) pyridine derivatives ( 3a–k ) by Chichibabin reaction has been reported. These compounds were synthesized by the reaction of 3-acetyl coumarin ( 1a ) or 5-bromo 3-acetyl coumarin ( 1b ) with substituted aromatic aldehydes ( 2a–k ) and ammonium acetate under acidic conditions and the structure was confirmed by FT-IR, 1 H NMR, 13 C NMR and Mass spectroscopic methods. The newly synthesized compounds ( 3a–k ) were evaluated for antimicrobial activity, DPPH free radical scavenging activity and ferrous ion-chelating ability. The mode of action of these active compounds was carried out by docking receptor GlcN6P synthase. Compounds 3a , 3b , 3c , and 3d have displayed potential antimicrobial activity and some of the compounds have shown promising antioxidant properties. [ABSTRACT FROM AUTHOR]