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Soymilk fermented with Streptococcus thermophilus grx02 (FSM) was evaluated for its antioxidant properties. Antioxidant effects of FSM in vitro were measured with 2, 2-diphenyl-1-picrylhydrazyl (DPPH) based assay and by determining the inhibitory effect on the formation for malonyldialdehyde (MDA), and on the ability to chelate ferrous ions; the respective average IC50 values were 49.5, 24.2 and 8.7 mg/mL. Antioxidant enzymatic activities in liver of alcohol-fed mice, biochemical markers in serum and an index of lipid peroxidation were determined, and additionally the changes in hepatocytes of ICR mice were compared. The results showed that, compared with the control group, alanine transaminase (ALT) activity, aspartate transaminase (AST) activity and triglycerides (TG) of negative group increased (p < 0.05). Moreover, the serum ALT and AST activities of FSM group was lower than negative group (p < 0.05). However, there was no significant difference (p > 0.05) in the albumin (ALB) and total protein (TP) values (in positive, negative, control, and FSM groups) in the serum. Compared with the negative group, alcohol dehydrogenase (ADH), superoxide dismutase (SOD) activities and glutathione (GSH) content increased in liver (p < 0.05) in FSM group. The MDA of FSM group in liver was lower than the negative group (p < 0.05). [ABSTRACT FROM AUTHOR]