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[Display omitted] • Novel metallic complexes of Cobalt [Co(II)] and Nickel [Ni(II)] complexes of 2-aminothiazole (ATZ) and thiocyanate ligands have been developed. • Antibacterial capabilities of ligands and their Co(II) and Ni(II) compounds were studied. • Complexes exhibit potential against the fungus than bacteria. Using the microwave irradiation approach, novel metallic complexes of Cobalt [Co(II)] and Nickel [Ni(II)] complexes of 2-aminothiazole (ATZ) and thiocyanate ligands [IUPAC Name: Di(2-aminothiazole) thiocyanato cobalt(II), Di(2-aminothiazole) thiocyanato nickel(II)] were created. The molecular formulas and the geometry of the complexes have been deduced by elemental analysis, molar conductance, magnetic moment, UV–visible, FT-IR, thermogravimetric analysis, cyclic voltammetry, and powder-XRD techniques. Molar conductance values indicate that the complexes are non-electrolyte (1:0) type. The complexes have octahedral structure is revealed by the magnetic moment and UV–visible spectra. The FT-IR spectra reveal that the 2-aminothiazole and thiocyanate ions are coordinated to the metal ion in a monodentate manner. The antibacterial capabilities of ligands and their Co(II) and Ni(II) compounds were studied against a restricted set of microorganisms utilizing the agar-well diffusion method and varying concentrations.When compared to free 2-aminothiazole ligand, the complexes exhibit possible activity against the fungus than bacteria. By assessing how well the complexes and ligands interact with the stable free radical DPPH, their ability to scavenge free radicals has been established. Comparing the complexes to the free ligand, the complexes exhibit greater antioxidant activity due to the fact that metal complexes are widely recognized for their capacity to accelerate medication action and boost therapeutic agent potency when they coordinate with a metal ion. The primary goal of this research is to develop multimodal medicinal drugs, which include studying the roles of 2-aminothiazole and its transition metal complexes. [ABSTRACT FROM AUTHOR]

The synthesis and characterization of Co(II) and Ni(II) mixed ligand complexes are derived from isoniazid, 9-fluorenoneandoxalate. The metal complexes were characterized on the basis of elemental analysis, IR, UV-visible, CV, PXRD, and molar conductance analytical data, viz., all the metal complexes were suggested in an octahedral geometry, respectively. The mixed ligand complexes are formed in the 1:1:2:1 (M:L1:L2:L3) ratios, as found from the elemental analyses, and originate to have the formula [M(L1)(L2)2(L3)]. Where M = Co(II), Ni(II), L1 = isoniazid, L2 = 9-fluorenone, and L3 = oxalate. The molar conductance data reveals that the complexes are non-electrolytes. The cyclic voltammogram of the Co(II) complex revealed that the quasi-reversible single electron transfer process and Ni(II) complex corresponding to a one-electron transfer process were observed during controlled potential electrolysis. IR spectra show that the ligands are coordinated to the metal ions through N and O donor sites of isoniazid-N, 9-fluorenone-O and oxalate-O. Magnetic moment values and UV-visible spectra were used to infer the coordinating of the geometrics of these complexes found to be octahedral. The PXRD patterns suggest that all the complexes are crystalline phases. The metal chelates have been screened for antimicrobial, antioxidant and anti-inflammatory activities, and our findings have been reported, explained and compared with some known antibiotics. [ABSTRACT FROM AUTHOR]

The Schiff base V2+ metal complex has been synthesized and characterized by various physiochemical, spectral and bio-potential studies viz., elemental analysis, metal estimation, molar conductance, magnetic moment and UV-Visible spectra, IR and Far-IR spectra. The Schiff base was synthesized by the condensation of Isoniazid and 4-chlorobenzaldehyde by the eco-friendly method. The elemental analysis of Schiff base and metal complex is confirmed by its stoichiometry and molecular formulae of them which is further confirmed metal estimation. Molar conductance of 10-3 M complex solution in acetonitrile shows the non-electrolytic nature. Magnetic moment and electronic spectral studies indicate the octahedral geometry of V2+ complex. The IR and Far-IR spectral data confirmed the complexing ability and metal chelates (M-N and M-O) of the metal chelate. In-vitro bio-potential activity (antibacterial and antifungal) of V2+ complex of Schiff base was assessed with various bacterial and fungal strains viz., E. coli and A. Niger by Agar well diffusion method. The DPPH free radical scavenging activity of Schiff base and its metal complex assessed by antioxidant activity was further confirmed by molecular docking studies of selected targeted protein viz., cytochrome p450. [ABSTRACT FROM AUTHOR]

The Schiff base (E)-N1[(E)-3-phenylallylidene]benzene-1,2-diamine was derived from the condensation of orthophenylenediamine and cinnamaldehyde. The Schiff base and its Zn(II) complex were characterized based on microanalysis, conductivity, IR, UV-Visible, NMR spectral studies. The analytical data suggest the stoichiometry to be 1:1 (M:L). The molar conductance data reveal that the complex is non-electrolyte. Melting points support the thermal stability of the Schiff base. The UV spectral data support the square planar geometry of the complex. Coordination of ligand was confirmed by the constant change in FT-IR. The NMR (¹H & 13C) spectra of the Schiff base and its complex were confirmed by the geometry and magnetic property them. The in-vitro antibacterial activity of the synthesized ligand and Zn(II) complex were screened for bio-potential activity using some microorganisms by agar well diffusion method. The antibacterial activity further confirmed by its pharmacokinetics study using Swiss ADME computational study. The antioxidant activity of the Schiff base and Zn(II) complex was also assessed by DPPH free radical scavenging method. IC50 values are also predicted and compared with standard ascorbic acid. [ABSTRACT FROM AUTHOR]