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This article discusses a case of cryoglobulinemic vasculitis complicating Sjögren's syndrome with IgA accumulation. The patient, a 90-year-old Japanese female, presented with bilateral lower limb purpura and joint pain. Laboratory investigations showed elevated levels of various markers, including immunoglobulin G (IgG), immunoglobulin A (IgA), and rheumatoid factor (RF). The patient was diagnosed with primary Sjögren's syndrome complicated by cryoglobulinemic vasculitis. Treatment with prednisolone and azathioprine improved the symptoms. The article highlights the importance of careful examination to identify underlying conditions such as Sjögren's syndrome or cryoglobulinemia in cases clinically diagnosed as IgA vasculitis. [Extracted from the article]

Patients with SSc often have anti-mitochondrial antibodies, as in our case.[4] Primary biliary cholangitis was excluded by hematological findings and a liver biopsy. We should think about the rare possibility that anti-mitochondrial antibodies occurred in her myositis.[7] Although the degree of serum CK was compatible, she did not have cardiac involvement, fibrosis or granulomatous change in the deltoid muscle biopsy. Limited cutaneous systemic sclerosis with myositis showing drug-induced liver injury and thrombotic microangiopathy. [Extracted from the article]