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Your search keyword '"McGahren, William J."' showing total 1 results
Start Over Author "McGahren, William J." Topic antineoplastic antibiotics -- research
1 results on '"McGahren, William J."'

1. Structure elucidation of calicheamicins beta1(super Br), gamma1(super Br), alpha2(super I), alpha3(super I), beta1(super I), gamma1(super I), and delta1(super I)

Author

Lee, May D., Dunne, Theresa S., Chang, Conway C., Siegel, Marshall M., Morton, George M., Ellestad, George A., McGahren, William J., and Borders, Donald B.

Subjects
Calicheamicin -- Research, Antineoplastic antibiotics -- Research, Molecular structure -- Research, Chemistry
Abstract

Degradation and spectroscopic studies are performed to elucidate the chemical structure of the antitumor antibiotic calicheamicin gamma1. The structural assignment of the glycosidic chain results from the methanolysis studies on calicheamicin gamma1 and N-acetylcalicheamicin gamma1. Chemical and spectroscopic evidence support the enediyne structure of calicheamicinone the existence of a 1,4-dehydrobenzene diradical as a reaction intermediate. The enediyne system is revealed to be a major determinant of the DNA-damaging capabilities of the calicheamicins.

Published
1992

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