1. Synthesis and antitumor activity of benzophenone compound.
- Author
-
Zhou BD, Wei RR, Li JL, Yu ZH, Weng ZM, Ruan ZP, Lin J, Fang YY, Xu GF, and Hu DB
- Subjects
- Benzophenones pharmacology, Cell Line, Tumor, Cell Proliferation, Drug Screening Assays, Antitumor, Molecular Structure, Structure-Activity Relationship, Antineoplastic Agents pharmacology
- Abstract
Seven benzophenone compounds were synthesized in one or two steps, then their antitumor activity was evaluated. The total yields ranged from 9% to 44%. Compounds 3c-5c exhibited obvious antitumor activity. Among them, compounds 3c and 4c exhibited excellent and broad-spectrum antitumor activity. Compound 3c exhibited much stronger inhibitory activities against fourteen cancer cells than cisplatin. In particular, compound 3c exhibited stronger cytotoxicity against hepatocarcinoma SMMC-7721 cells than Taxol, with a half maximal inhibitory concentration (IC
50 ) of approximately 0.111 μM. These results demonstrated that compounds 3c , 4c and 5c were very promising antitumor leads for further structural modification.- Published
- 2022
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