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1. Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery.

Author

Shetty D, Skorjanc T, Olson MA, and Trabolsi A

Subjects
Antineoplastic Agents chemistry, Calixarenes chemical synthesis, Calixarenes toxicity, Camptothecin chemistry, Drug Carriers chemical synthesis, Drug Carriers toxicity, Drug Liberation, Humans, Hydrogen-Ion Concentration, MCF-7 Cells, Nanocapsules toxicity, Phenols chemical synthesis, Phenols toxicity, Antineoplastic Agents pharmacology, Calixarenes chemistry, Camptothecin pharmacology, Drug Carriers chemistry, Nanocapsules chemistry, Phenols chemistry
Abstract

Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.

Published
2019
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