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Your search keyword '"Williams, Craig M."' showing total 1 results
Start Over Author "Williams, Craig M." Topic antineoplastic agents Topic baeyer-villiger rearrangement Topic croton (genus)
1 results on '"Williams, Craig M."'

1. Unprecedented 1,14- seco-Crotofolanes from Croton insularis: Oxidative Cleavage of Crotofolin C by a Putative Homo-Baeyer-Villiger Rearrangement.

Author

Maslovskaya, Lidiya A., Savchenko, Andrei I., Pierce, Carly J., Gordon, Victoria A., Reddell, Paul W., Parsons, Peter G., and Williams, Craig M.

Subjects
CROTON (Genus), INTERMEDIATES (Chemistry), BIOSYNTHESIS, DITERPENES, ANTINEOPLASTIC agents, CHEMICAL decomposition
Abstract

EBC-162 isolated from Croton insularis, obtained from the northern rainforest of Australia, was structurally affirmed as crotofolin C ( 4). Novel oxidative degradation products, EBC-233 and EBC-300, which are the first crotofolane endoperoxides, were also isolated. Both endoperoxides were found to be stable intermediates, which are proposed to undergo an unprecedented homo-Baeyer-Villiger biosynthetic rearrangement to give a new class of 1,14- seco-crotofolane diterpenes. Prolonged storage of all isolates assisted in authenticating their natural product status. Anticancer activities of reported compounds are presented. [ABSTRACT FROM AUTHOR]

Published
2014
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