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Introduction: During the last decades, there was a great interest in the development of bioactive dental material with the ability to interact and induce dental tissues. Biodentine is a calcium silicate-based cement that has beneficial effects on pulp cells and promotes the formation of tertiary dentin. Aim: To analyze the literature on biodentine, as well as its antimicrobial activity, its setting capacity, its clinical applications and its biological properties. Methodology: Using the keywords biodentine, root canal sealing materials, epidemiology, diagnosis, clinical manifestations, antimicrobial resistance, and treatment, the MEDLINE/PubMed and Science Direct databases were searched, with emphasis on the last 5 years. It was evaluated with the PRISMA and AMSTAR-2 guidelines. Results: The antimicrobial activity of Biodentine has been greater against strains such as Streptococcus sanguis, Enterococcus faecalis, Escherichia coli and Candida albicans. Biodentine has benefits such as excellent sealability, biocompatibility, good dimensional stability with the advantage of a setting time of 12 to 13 minutes, less than MTA. Materials used in the vital pulp method must have biocompatibility and bioactivity to promote pulp cell activity. Biodentine induces the differentiation of pulp cells into odontoblast-like cells, formation of mineralized tissue and restorative dentin. Conclusion: The composition and its applications have shown sufficient basis to perform an adequate antimicrobial activity, as well as its setting time improved to 12 minutes. Vital pulp therapy is one of the main uses of this material as it is a widely accepted material for dentin tissues due to its high biological compatibility.