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Your search keyword '"Mbah JA"' showing total 2 results
Start Over Author "Mbah JA" Topic antimalarials
2 results on '"Mbah JA"'

1. Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity.

Author

Efange SM, Brun R, Wittlin S, Connolly JD, Hoye TR, McAkam T, Makolo FL, Mbah JA, Nelson DP, Nyongbela KD, and Wirmum CK

Subjects
Antimalarials chemistry, Chloroquine pharmacology, Drug Resistance drug effects, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Plant Roots chemistry, Plasmodium falciparum drug effects, Sesquiterpenes chemistry, Stereoisomerism, Antimalarials isolation & purification, Antimalarials pharmacology, Cyperaceae chemistry, Plants, Medicinal chemistry, Sesquiterpenes isolation & purification, Sesquiterpenes pharmacology
Abstract

Okundoperoxide (1) was isolated by bioassay-guided fractionation of extracts from Scleria striatinux (syn. S. striatonux). The compound contains a cyclic endoperoxide structural moiety and possesses moderate antimalarial activity.

Published
2009
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2. Anti-plasmodial sesquiterpenoids from the African Reneilmia cincinnata.

Author

Tchuendem MH, Mbah JA, Tsopmo A, Ayafor JF, Sterner O, Okunjic CC, Iwu MM, and Schuster BM

Subjects
Animals, Antimalarials chemistry, Fruit chemistry, Nuclear Magnetic Resonance, Biomolecular, Plant Extracts chemistry, Plant Extracts isolation & purification, Plant Extracts pharmacology, Plasmodium falciparum drug effects, Plasmodium falciparum growth & development, Sesquiterpenes chemistry, Antimalarials isolation & purification, Antimalarials pharmacology, Sesquiterpenes isolation & purification, Sesquiterpenes pharmacology, Zingiberales chemistry
Abstract

A new isodaucane sesquiterpenoid, 6,7,10-trihydoxyisodaucane, was isolated from the fruits of Reneilmia cincinnata, together with the known sesquiterpenoids oplodiol, oplopanone, 5E,10(14)-germacradien-1 beta, 4 beta-diol, 1(10)E,5E-germacradien-4 alpha-ol and eudesman-1,4,7-triol. A large amount of 5-hydroxy-3,7,4'-trimethoxyflavone was also isolated. Their structures were established by NMR techniques using 1D and 2D experiments. Three of the known sesquirernenoids exhibited noteworthy anti-plasmodial activity against Plasmodium falciparum strains.

Published
1999
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