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Start Over Descriptor "białko C-reaktywne" Topic antihypertensive therapy
2 results on '"białko C-reaktywne"'

1. Short-term antihypertensive therapy lowers the C-reactive protein level.

Author

Madej, Andrzej, Bołdys, Aleksandra, Bułdak, Łukasz, Łabuzek, Krzysztof, Basiak, Marcin, and Okopień, Bogusław

Subjects
*ANTIHYPERTENSIVE agents, *C-reactive protein, *CARDIOVASCULAR diseases risk factors, *CARDIOVASCULAR disease treatment, *HYPERTENSION, *DRUG efficacy, *BLOOD pressure, *BISOPROLOL
Abstract

Introduction: There is a growing body of data concerning significant interactions between markers of inflammation and cardiovascular diseases such as hypertension accompanied by elevated levels of plasma C-reactive protein (CRP). Therefore CRP is thought to be an independent risk factor of cardiovascular diseases. Material/Methods: The aim of this study was to evaluate the effects of antihypertensive therapy (perindopril, bisoprolol and combined therapy) on plasma CRP concentration in 67 subjects with mild or moderate hypertension who have been treatment-naive and otherwise healthy. Results: The results show a correlation between CRP level and blood pressure values. BP reduction was associated with a decrease in CRP concentration. The CRP-lowering effect of perindopril and bisoprolol was comparable and the degree of reduction might reflect their similar influence on blood pressure. Combined treatment influenced the CRP level to a greater extent than both monotherapies. Conclusions: Plasma CRP level was lowered by antihypertensive therapy independently of the drug applied. The CRP level did not normalize completely in moderate hypertensive patients. [ABSTRACT FROM AUTHOR]

Published
2012

2. Short-term antihypertensive therapy lowers the C-reactive protein level

Author

Madej, A., Bołdys, A., Bułdak, L., Łabuzek, K., Marcin Basiak, and Okopień, B.

Subjects
Adult, Male, leczenie nadciśnienia, lcsh:R, lcsh:Medicine, Blood Pressure, Middle Aged, białko C-reaktywne, Drug Administration Schedule, C-Reactive Protein, Hypertension, Perindopril, Bisoprolol, Humans, Drug Therapy, Combination, Female, antihypertensive therapy, Antihypertensive Agents, Biomarkers
Abstract

Introduction:There is a growing body of data concerning significant interactions between markers of inflammation and cardiovascular diseases such as hypertension accompanied by elevated levels of plasma C-reactive protein (CRP). Therefore CRP is thought to be an independent risk factor of cardiovascular diseases.Material/Methods:The aim of this study was to evaluate the effects of antihypertensive therapy (perindopril, bisoprolol and combined therapy) on plasma CRP concentration in 67 subjects with mild or moderate hypertension who have been treatment-naive and otherwise healthy.Results:The results show a correlation between CRP level and blood pressure values. BP reduction was associated with a decrease in CRP concentration. The CRP-lowering effect of perindopril and bisoprolol was comparable and the degree of reduction might reflect their similar influence on blood pressure. Combined treatment influenced the CRP level to a greater extent than both monotherapies.Conclusions:Plasma CRP level was lowered by antihypertensive therapy independently of the drug applied. The CRP level did not normalize completely in moderate hypertensive patients.

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