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Immune complexes were detected by the platelet aggregation technique in sera of six out of twenty-six patients with sarcoidosis. Five of these patients had acute bilateral hilar lymphoma syndrome, four of them with concomitant erythema nodosum. The size of the immune complexes was 19S or larger. [ABSTRACT FROM AUTHOR]

The synovial membrane of healthy volunteers was analysed by immunohistochemical staining of biopsies sampled under direct vision at arthroscopy or obtained blindly by needle. Infiltrating Leu-4+ T lymphocytes were found scattered in all biopsies but frequently also perivascularly accumulated. A majority of the synovial lining cells expressed either the OKMI monocyte/macrophage marker or HLA-DR antigens. Some OKM1- HLA-DR+ lining cells also expressed the Leu-3a T 'helper' cell marker. In the sublining tissue non-lymphoid cells with varying morphology including macrophage- and fibrocyte-like cells were found expressing either HLA-DR. or Leu-3a, or both antigens simultaneously, whereas OKMI+ macrophage-like sublining cells were rare. The perivascular T lymphocyte accumulation as well as the phenotypic heterogeneity of infiltrating and residing cells, previously thought indicative of synovitis, were thus also found in the synovial membrane of healthy individuals. [ABSTRACT FROM AUTHOR]