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Your search keyword '"Tolle, R"' showing total 2 results
Start Over Author "Tolle, R" Topic antigens, protozoan
2 results on '"Tolle, R"'

1. A direct and rapid sequencing strategy for the Plasmodium falciparum antigen gene gp190/MSA1.

Author

Pan W, Tolle R, and Bujard H

Subjects
Animals, Base Sequence, DNA Primers genetics, DNA, Protozoan genetics, Malaria Vaccines genetics, Merozoite Surface Protein 1, Molecular Sequence Data, Polymerase Chain Reaction, Vaccines, Synthetic genetics, Antigens, Protozoan genetics, Antigens, Surface genetics, Genes, Protozoan, Plasmodium falciparum genetics, Plasmodium falciparum immunology, Protein Precursors genetics, Protein Precursors immunology, Protozoan Proteins genetics, Protozoan Proteins immunology, Sequence Analysis, DNA methods
Published
1995
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2. A prospective study of the association between the human humoral immune response to Plasmodium falciparum blood stage antigen gp190 and control of malarial infections.

Author

Tolle R, Früh K, Doumbo O, Koita O, N'Diaye M, Fischer A, Dietz K, and Bujard H

Subjects
Adult, Animals, Antibodies, Bacterial, Antibodies, Protozoan biosynthesis, Antibodies, Protozoan blood, Base Sequence, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Hemoglobins analysis, Humans, Infant, Middle Aged, Molecular Sequence Data, Peptide Fragments immunology, Predictive Value of Tests, Prospective Studies, Recurrence, Antibodies, Protozoan immunology, Antigens, Protozoan immunology, Malaria, Falciparum immunology, Plasmodium falciparum pathogenicity, Protozoan Proteins immunology
Abstract

The human humoral immune response to the Plasmodium falciparum merozoite surface antigen gp190 was analyzed to determine the rate of reinfection by the parasite and the ability to control parasite density. The prospective study was carried out in a West African village where malaria is hyperendemic. No correlation between the antibody titers and protection against infection was observed within the group of children. Positive and negative associations of antibody specificities with protection against and/or control of parasitemia were, however, found for adolescents and adults, respectively. Thus, in adolescents, the presence of antibodies to gp190 fragment M6 correlates with a 50% reduced risk of P. falciparum infection and an increased ability to control parasitemia, whereas in adults, the humoral response to some of the polymorphic regions of gp190 associates with an increased risk of infection.

Published
1993
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