1. Seroreversion to Chlamydia trachomatis Pgp3 Antigen Among Children in a Hyperendemic Region of Amhara, Ethiopia.
- Author
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Tedijanto C, Aragie S, Gwyn S, Wittberg DM, Zeru T, Tadesse Z, Chernet A, Thompson IJB, Nash SD, Lietman TM, Martin DL, Keenan JD, and Arnold BF
- Subjects
- Humans, Ethiopia epidemiology, Child, Preschool, Female, Male, Infant, Longitudinal Studies, Child, Endemic Diseases, Chlamydia trachomatis immunology, Antigens, Bacterial immunology, Immunoglobulin G blood, Immunoglobulin G immunology, Trachoma epidemiology, Trachoma microbiology, Trachoma immunology, Antibodies, Bacterial blood, Antibodies, Bacterial immunology, Bacterial Proteins immunology
- Abstract
Monitoring trachoma transmission with antibody data requires characterization of decay in IgG to Chlamydia trachomatis antigens. In a 3-year longitudinal cohort in a high-transmission setting, we estimated a median IgG half-life of 3 years and a seroreversion rate of 2.5 per 100 person-years (95% confidence interval, 1.6-3.5). Clinical Trials Registration NCT02754583., Competing Interests: Potential conflicts of interest. All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed., (© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2024
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