1. [Cryohemosorption--a method of removal of lipoprotein-antibody immune complexes and other atherogenic substances in patients with atherosclerosis].
- Author
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Klimov AN, Denisenko AD, Belotserkovskiĭ MV, Gurevich KIa, Vinogradov AG, Makoveĭchuk EG, Vasil'eva LE, Oleĭnik IA, Tikhonova LN, and Sitnikova OD
- Subjects
- Adult, Aged, Apolipoproteins analysis, Arteriosclerosis blood, Arteriosclerosis immunology, Autoimmune Diseases, Cholesterol blood, Evaluation Studies as Topic, Female, Fibrinogen analysis, Fibronectins analysis, Humans, Immunoglobulin G immunology, Male, Middle Aged, Triglycerides blood, Antigen-Antibody Complex, Arteriosclerosis therapy, Autoantibodies immunology, Hemoperfusion, Lipoproteins immunology
- Abstract
The efficacy of extracorporeal cryohemosorption was estimated in the treatment of atherosclerotic patients in terms of the autoimmune theory of the pathogenesis of this disease. There was a slight decrease in the plasma levels of total cholesterol and triglycerides, there was over 2-fold reduction in the plasma levels of fibrinogen and fibronectin. All major components of apo B-containing lipoproteins and immunoglobulin G were found as part of the cryoprecipitate. An extremely high concentration of lipid hydroperoxides in the precipitate suggest that cryoprecipitation removes not only autoimmune complexes, but highly-atherogenic peroxide-modified lipoproteins. The three-fold decrease in the levels of lipoprotein-antibody complexes resulted in lower atherogenicity of apo B-containing lipoproteins. It is suggested that the mechanism responsible for beneficial clinical action of cryohemosorption sessions is largely associated with the removal of autoimmune lipoprotein-antibody complexes and peroxide-modified apo B-containing lipoproteins than correction of lipid metabolism.
- Published
- 1994