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Start Over Author "Lefebure, M." Topic antigen presenting cells
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1. CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo.

Author

Gregory, G P, Hogg, S J, Kats, L M, Vidacs, E, Baker, A J, Gilan, O, Lefebure, M, Martin, B P, Dawson, M A, Johnstone, R W, and Shortt, J

Subjects
LYMPHOMAS, B cells, LYMPHATIC diseases, ANTIGEN presenting cells, LYMPHOCYTES
Abstract

The article presents a study that determines the role of CDK9 inhibitor in inducing durable apoptotic response in aggressive B-cell lymphoma. Overview of the background of the study which describe the durable responses to dinaciclib in aggressive MYC-driven lymphoma is provided. The result of the study which suggests that CDK9 inhibitors are highly effective MYC-driven lymphomas.

Published
2015
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