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Your search keyword '"M von Strandtmann"' showing total 5 results
Start Over Author "M von Strandtmann" Topic antifungal agents
5 results on '"M von Strandtmann"'

3. Antifungal agents. 5. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. Alcohol, ketone, aldehyde, and oxime analogues of ambruticin.

Author

Connor DT and von Strandtmann M

Subjects
Alcohols chemical synthesis, Alcohols pharmacology, Aldehydes chemical synthesis, Aldehydes pharmacology, Bacteria drug effects, Fungi drug effects, Ketones chemical synthesis, Ketones pharmacology, Myxococcales, Oximes chemical synthesis, Oximes pharmacology, Pyrans chemical synthesis, Structure-Activity Relationship, Antifungal Agents chemical synthesis
Abstract

Alcohol, ketone, aldehyde, and oxime analogues of ambruticin (1) were prepared. The analogues were tested against Histoplasma capsulatum, Microsporum fulvum, Candida albicans, and Streptococcus pyogenes. Structure-activity relationships are described. Increasing the bulk of substituent at C1 and C5 reduces antifungal activity.

Published
1979
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4. Antifungal agents. 4. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. Ester and amide analogues of ambruticin.

Author

Connor DT and von Strandtmann M

Subjects
Antifungal Agents pharmacology, Bacteria drug effects, Esters chemical synthesis, Fungi drug effects, Myxococcales, Pyrans chemical synthesis, Pyrans pharmacology, Structure-Activity Relationship, Amides chemical synthesis, Antifungal Agents chemical synthesis
Abstract

A series of ester and amide analogues of ambruticin (1) was prepared. The analogues were tested against Histoplasma capsulatum, Microsporum fulvum, Candida albicans and Streptococcus pyogenes. Structure-activity relationships are described.

Published
1979
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5. Ambruticin (W7783), a new antifungal antibiotic

Author

G. Kanter, M. Von Strandtmann, Ann Gutt, Sidney Roemer, R. C. Greenough, Samuel M. Ringel, David T. Connor, and B. Blair

Subjects
Pharmacology, Polyangium, Myxobacteriales, Antifungal Agents, Magnetic Resonance Spectroscopy, Spectrophotometry, Infrared, biology, medicine.drug_class, Antifungal antibiotic, fungi, Antibiotics, Microbial Sensitivity Tests, AMBRUTICIN, biology.organism_classification, Mass Spectrometry, Microbiology, Lethal Dose 50, Mice, Fermentation, Drug Discovery, medicine, Animals, Myxococcales, Bacteria, Pyrans
Abstract

Ambruticin represents a new class of antibiotics isolated from a strain of Polyangium cellulosum var. firlvum, a bacterium belonging to the class Myxobacteriales. This antibiotic is a cyclopropyl-polyene-pyran acid and is active in vitro against fungi.

Published
1977
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