1. Emerging Trichosporon asahii in elderly patients: epidemiological and molecular analysis by the DiversiLab system.
- Author
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Treviño M, García-Riestra C, Areses P, García X, Navarro D, Suárez FJ, López-Dequidt IA, Zaragoza O, and Cuenca-Estrella M
- Subjects
- Aged, Aged, 80 and over, Catheter-Related Infections drug therapy, Catheter-Related Infections epidemiology, Catheter-Related Infections microbiology, Humans, Male, Microbial Sensitivity Tests, Middle Aged, Molecular Epidemiology, Molecular Typing methods, Mycological Typing Techniques methods, Triazoles pharmacology, Triazoles therapeutic use, Trichosporon drug effects, Trichosporon genetics, Trichosporonosis drug therapy, Urinary Tract Infections drug therapy, Urinary Tract Infections epidemiology, Urinary Tract Infections microbiology, Antifungal Agents pharmacology, Antifungal Agents therapeutic use, Trichosporon classification, Trichosporon isolation & purification, Trichosporonosis epidemiology, Trichosporonosis microbiology
- Abstract
Trichosporon asahii has been recognized as an emerging opportunistic agent for invasive infections, mainly in immunocompromised patients. Urinary tract infections by this pathogen may also occur, especially in patients with urinary obstruction or those undergoing vesical catheterization and antibiotic treatment. Many outbreaks of Trichosporon spp. have been detected after urinary catheter manipulations. We report the molecular-epidemiological characterization of T. asahii in our institution using the DiversiLab system for the molecular strain typing and compare three different methods for susceptibility testing. Our results present T. asahii as an emergent pathogen in elderly patients with urinary drainage devices that can be adequately treated with triazoles, with voriconazole being the most active. Broth dilution and Vitek 2 had good concordance, while Etest showed more discrepancies. In addition, the DiversiLab system for clonal strain typing may be a useful tool for fast and accurate management of nosocomial outbreaks.
- Published
- 2014
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