1. Substituted indoloquinolines as new antifungal agents.
- Author
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Ablordeppey SY, Fan P, Li S, Clark AM, and Hufford CD
- Subjects
- Alkaloids chemistry, Alkaloids pharmacology, Antifungal Agents chemistry, Antifungal Agents pharmacology, Indole Alkaloids, Indoles chemical synthesis, Indoles chemistry, Indoles pharmacology, Microbial Sensitivity Tests, Mitosporic Fungi drug effects, Quinolines chemistry, Quinolines pharmacology, Structure-Activity Relationship, Antifungal Agents chemical synthesis, Quinolines chemical synthesis
- Abstract
Cryptolepine (2) possesses desirable properties to serve as a lead in developing new antifungal agents. Using SAR techniques, several analogues of cryptolepine were designed to increase potency and to broaden the antifungal spectrum over several opportunistic microorganisms. A number of 2-substituted indoloquinolines have been synthesized and evaluated in antifungal screens and several have been shown to increase potency and expand the antifungal spectrum of cryptolepine. Comparison of MICs of a number of these analogues with standard antifungal agents, shows them to be comparable to Amphotericin B and Ketoconazole.
- Published
- 2002
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