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Your search keyword '"Al-Taweel, Areej"' showing total 3 results
Start Over Author "Al-Taweel, Areej" Topic antifungal agents
3 results on '"Al-Taweel, Areej"'

1. Antibacterial and Antifungal Sesquiterpenoids from Aerial Parts of Anvillea garcinii .

Author

Perveen S, Alqahtani J, Orfali R, Aati HY, Al-Taweel AM, Ibrahim TA, Khan A, Yusufoglu HS, Abdel-Kader MS, and Taglialatela-Scafati O

Subjects
Magnetic Resonance Spectroscopy, Microbial Sensitivity Tests, Molecular Structure, Plant Extracts chemistry, Plant Extracts pharmacology, Plants, Medicinal, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Antifungal Agents chemistry, Antifungal Agents pharmacology, Asteraceae chemistry, Plant Components, Aerial chemistry, Sesquiterpenes chemistry, Sesquiterpenes pharmacology
Abstract

Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia-11(13)en-12,6α-olide ( 1 ), and germacrane, 9β-hydroxyparthenolide-9- O -β-D-glucopyranoside ( 2 ), classes have been isolated from the leaves of the Saudi medicinal plant Anvillea garcinii along with seven known compounds ( 3 - 9 ). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of 1 - 9 were screened against seven different pathogenic microbes, and compounds 1 - 3 showed a potent antifungal activity.

Published
2020
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2. Antimicrobial guaianolide sesquiterpenoids from leaves of the Saudi Arabian plant Anvillea garcinii.

Author

Perveen S, Alqahtani J, Orfali R, Al-Taweel AM, Yusufoglu HS, Abdel-Kader MS, and Taglialatela-Scafati O

Subjects
Anti-Bacterial Agents isolation & purification, Antifungal Agents isolation & purification, Microbial Sensitivity Tests, Molecular Structure, Phytochemicals isolation & purification, Phytochemicals pharmacology, Plant Leaves chemistry, Plants, Medicinal chemistry, Saudi Arabia, Sesquiterpenes, Guaiane isolation & purification, Anti-Bacterial Agents pharmacology, Antifungal Agents pharmacology, Asteraceae chemistry, Sesquiterpenes, Guaiane pharmacology
Abstract

Anvillea garcinii is a medicinal plant used in the Arab region for intestinal diseases, lungs and liver diseases, digestive problems, and as an anti-diabetic. Repeated chromatographic purifications of A. garcinii leaves led to the isolation of two undescribed guaiane sesquiterpene lactones (1-2), along with four known germacranolides (3-6). The structures of the new compounds were established using spectroscopic (1D, 2D NMR) and spectrometric methods (ESIMS). Compounds 1 and 2 were shown to possess hydroxyl substituents at position 9, a structural feature rarely reported in guaianolide-type sesquiterpenes. The antimicrobial activity of 1-6 was screened against five different gram-positive/negative bacteria and the fungi Candida albicans and C. parapsilosis. Compounds 1 and 2 displayed remarkable antifungal effect against C. albicans and C. parapsilosis and potent antibacterial activities against Staphylococcus aureus., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Published
2019
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3. Antimicrobial guaianolide sesquiterpenoids from leaves of the Saudi Arabian plant Anvillea garcinii

Author

Orazio Taglialatela-Scafati, Maged S. Abdel-Kader, Raha Orfali, Jawaher H. Al-Qahtani, Hasan Soliman Yusufoglu, Shagufta Perveen, Areej Mohammad Al-Taweel, Perveen, Shagufta, Alqahtani, Jawaher, Orfali, Raha, Al-Taweel, Areej Mohammad, Yusufoglu, Hasan Soliman, Abdel-Kader, Maged Saad, and Taglialatela-Scafati, Orazio

Subjects
Sesquiterpene, Antifungal, Antifungal Agents, Anvillea garcinii, medicine.drug_class, Phytochemicals, Saudi Arabia, Microbial Sensitivity Tests, Antimicrobial activity, Asteraceae, medicine.disease_cause, 01 natural sciences, chemistry.chemical_compound, Sesquiterpenes, Guaiane, Drug Discovery, medicine, Candida albicans, Pharmacology, Plants, Medicinal, Traditional medicine, biology, Molecular Structure, 010405 organic chemistry, Chemistry, Drug Discovery3003 Pharmaceutical Science, General Medicine, Antimicrobial, biology.organism_classification, Corpus albicans, 0104 chemical sciences, Anti-Bacterial Agents, Plant Leaves, 010404 medicinal & biomolecular chemistry, Staphylococcus aureus, Bacteria, Guaianolide
Abstract

Anvillea garcinii is a medicinal plant used in the Arab region for intestinal diseases, lungs and liver diseases, digestive problems, and as an anti-diabetic. Repeated chromatographic purifications of A. garcinii leaves led to the isolation of two undescribed guaiane sesquiterpene lactones (1–2), along with four known germacranolides (3–6). The structures of the new compounds were established using spectroscopic (1D, 2D NMR) and spectrometric methods (ESIMS). Compounds 1 and 2 were shown to possess hydroxyl substituents at position 9, a structural feature rarely reported in guaianolide-type sesquiterpenes. The antimicrobial activity of 1–6 was screened against five different gram-positive/negative bacteria and the fungi Candida albicans and C. parapsilosis. Compounds 1 and 2 displayed remarkable antifungal effect against C. albicans and C. parapsilosis and potent antibacterial activities against Staphylococcus aureus.

Published
2019

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