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WOS: 000485852800021 In this study, chemical composition determination and in vitro antibacterial and antifungal effects of essential oils of Laurus nobilis flowers and leaves grown West Anatolian ecological conditions were investigated. Antibacterial and antifungal activities were evaluated by Minimum Inhibition Concentration (MIC) method. Extractions were carried out with clevenger apparatus and essential oil compositions were determined by Gas Chromatography-Mass Spectrometry (GC-MS). According to the results of the gas chromatography-mass spectrometry analysis, camphene (28.46 %), 1,8-cineole (34.08%) were found to be highest in the essential oil obtained from Laurus nobilis leaves. 3-ethyl-6-(methoxycarbonyl)-2-naphthol (16.10%), camphene (18.14%), were found to be highest in the essential oil obtained from Laurus nobilis flowers. MIC values of essential oils of flower and leave parts of L. nobilis range from 1.5625 mu L/mL to 6.25 mu L/mL against test bacteria. As a result, it is thought that the essential oil content differs in quantity and composition from the past studies, due to the different geographical and environmental effects of the plant.

This study was carried out with the aim of determining the antifungal effect of the essential oil isolated from Achillea millefolium subsp. millefolium plant against pathogenic fungi. In order to test the antifungal effect of the oil, an analysis was conducted on a total of 4 pathogen fungi which included Candida albicans, Candida tropicalis, Candida parapsilosis and Saccharomyces cerevisiae, and the effect of the essential oil on the growth of these fungi was investigated. The essential oil of A. millefolium ssp. millefolium had varying degrees of effect on the tested fungi. The highest antifungal effect was found against S. cerevisiae; whereas the lowest antifungal effect was found against C. parapsilosis. Nystatin showed a higher activity than the essential oil of A. millefolium subsp. millefolium against the tested fungi. MIC values of the essential oil against the tested fungi ranged from 1.25 μl/ml to 10 μl/ml. The results obtained indicate that essential oil of A. millefolium subsp. millefolium can be used as an alternative to antifungal agents such as amphotericin, ketoconazole, and fluconazole.