1. Evaluation of safety of warfarin in combination with antiplatelet therapy for patients treated with coronary stents for acute myocardial infarction.
- Author
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Mattichak SJ, Reed PS, Gallagher MJ, Boura JA, O'Neill WW, and Kahn JK
- Subjects
- Aged, Coronary Angiography, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction diagnostic imaging, Myocardial Infarction surgery, Postoperative Period, Retrospective Studies, Risk Factors, Safety, Secondary Prevention, Treatment Outcome, Anticoagulants therapeutic use, Blood Vessel Prosthesis Implantation instrumentation, Myocardial Infarction drug therapy, Platelet Aggregation Inhibitors therapeutic use, Stents, Warfarin therapeutic use
- Abstract
The safety and efficacy of treating recently stented patients on combination antiplatelet therapy with warfarin for clinical indications in unknown. Therefore, we examined the use of warfarin in a population of patients with myocardial infarction (MI) treated with coronary stenting. We performed a retrospective analysis comparing patients who underwent successful coronary stenting for acute MI and were discharged on either warfarin and combination platelet therapy for clinical indications or combination antiplatelet therapy alone. There was a nonsignificant trend toward reinfarction at 6 and 12 months in warfarin-treated patients. Warfarin-treated patients had significantly higher rates of transfusion compared to nonwarfarin-treated patients at 12 months (21% vs 0%, P=0.028). There were no significant predictors of reinfarction in 6 and 12 months in multivariate analysis. These data demonstrate that warfarin anticoagulation, in combination with successful coronary stenting for acute MI and antiplatelet therapy, does not reduce risk of reinfarction but is associated with increased rates of transfusion.
- Published
- 2005
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