1. Pharmacokinetic variability of anticoagulants in patients with cancer-associated thrombosis: Clinical consequences.
- Author
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Bellesoeur A, Thomas-Schoemann A, Allard M, Smadja D, Vidal M, Alexandre J, Goldwasser F, and Blanchet B
- Subjects
- Humans, Neoplasms blood, Neoplasms therapy, Risk Assessment, Thrombosis blood, Thrombosis etiology, Tissue Distribution, Treatment Outcome, Anticoagulants pharmacokinetics, Anticoagulants therapeutic use, Neoplasms complications, Thrombosis drug therapy
- Abstract
The use of anticoagulants in patients with cancer is challenging as several co-morbidities modifying pharmacokinetic (PK) parameters and significant drug-drug interactions with concomitant anti-neoplastic therapies may lead to PK variability resulting in increased risk of thrombosis or bleeding. Data on the management of patients with cancer-associated thrombosis (CAT) in real life are scarce since patients with cancer presenting with significant comorbidities tend to be excluded from large trials. This review is mostly based on case-reports and pharmacokinetics in an attempt to provide oncologists, with relevant orientation based on our best knowledge to date. Overall, low-molecular-weight heparins (LMWH) are the preferred option for the long-term prophylaxis and treatment of CAT as their benefit-risk was shown superior to vitamin K antagonists (VKA). Direct oral anticoagulants (DOAC) may represent an alternative to LMWH provided that a favorable benefit-risk in patients with CAT is evidenced in the future. We recommend a systematic risk-assessment including body composition, multiple medication, and renal function. Moreover a systematic and early discussion between pharmacist and oncologist should optimize the benefit-risk ratio for each patient., (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Published
- 2018
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