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A series of 3-(1 H-imidazo[4,5- c]pyridin-2-yl)-1,5-diarylpyridin-2(1 H)-one derivatives were designed and synthesized as potential anticoagulant agents. The 1,5-diarylpyridin-2(1 H)-ones, key intermediates of these anticoagulants, were synthesized by a simple reaction of 2-aryl vinamidinium salts with ethyl 3-oxo-3-(arylamino)propanoate derivatives. The prothrombin time in canine blood showed that amino and hydroxymethyl derivatives therein possess obvious anticoagulant abilities (PT = 17.07 s). [ABSTRACT FROM AUTHOR]