1. Antiretroviral therapy effect on specific antibodies spectrum changes to HIV-1 individual antigenes from persons infected with different virus subtypes
- Author
-
L. N. Lukhverchik, G. I. Alatortseva, L. N. Nesterenko, V. V. Dotsenko, I. I. Amiantova, M. V. Zhukina, V. Yu. Kabargina, M. R. Bobkova, E. V. Kazennova, and V. V. Zverev
- Subjects
0301 basic medicine ,subtype of hiv-1 ,030231 tropical medicine ,030106 microbiology ,antiretroviral therapy ,Human immunodeficiency virus (HIV) ,Medicine (miscellaneous) ,hiv-infection ,medicine.disease_cause ,Microbiology ,Virus ,03 medical and health sciences ,linear immunoassay ,0302 clinical medicine ,Blood serum ,Antigen ,Medicine ,antibodies ,biology ,medicine.diagnostic_test ,business.industry ,General Medicine ,Antiretroviral therapy ,QR1-502 ,Immunoassay ,Immunology ,biology.protein ,Antibody ,business - Abstract
Aim. To estimate the antibodies (Ab) level to HIV-1 antigens in persons infected with virus various subtypes, which received and didn’t receive antiretroviral therapy (ART). Materials and methods . Blood serum samples of HIV-1-infected with subtypes A1, B and C (ART+) — 40 persons, (ART-) — 29 persons. Ab were determined by modified linear immunoassay. Positivity indices for each antigen were calculated for each sample. Results . Multidirectional changes in the Ab level to HIV-1 antigens were revealed in persons infected with virus various subtypes at the ART background and without it. Conclusion. The study of Ab spectrum changes in persons infected with virus various subtypes at the ART background is promising for the additional dynamic criteria development for HIV infection progress estimation.
- Published
- 2019