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1. Inhibition of tumor angiogenesis by globotriaosylceramide immunotargeting.

Author

Birklé, Stéphane, Desselle, Ariane, Chaumette, Tanguy, Gaugler, Marie-Hélène, Cochonneau, Denis, Fleurence, Julien, Dubois, Nolwenn, Hulin, Philippe, Aubry, Jacques, and Paris, François

Subjects
*IMMUNOTHERAPY, *NEOVASCULARIZATION, *METASTASIS, *BLOOD-vessel development, *TUMOR treatment
Abstract

Current antiangiogenic immunotherapeutic strategies mainly focus on the blockade of circulating cytokines or receptors that are overexpressed by endothelial cells. We proposed globotriaosylceramide (Gb3) as a viable alternative target for antiangiogenic therapies. In this setting, we developed an anti-Gb3 antibody and validated its therapeutic efficacy in metastatic tumor models. [ABSTRACT FROM AUTHOR]

Published
2013
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