1. KSHV induces immunoglobulin rearrangements in mature B lymphocytes.
- Author
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Totonchy, Jennifer, Osborn, Jessica M., Chadburn, Amy, Nabiee, Ramina, Argueta, Lissenya, Mikita, Geoffrey, and Cesarman, Ethel
- Subjects
IMMUNOGLOBULINS ,LYMPHOCYTES ,B cells ,GENE expression ,IMMUNE response - Abstract
Kaposi Sarcoma Herpesvirus (KSHV/HHV-8) is a B cell tropic human pathogen, which is present in vivo in monotypic immunoglobulin λ (Igλ) light chain but polyclonal B cells. In the current study, we use cell sorting to infect specific B cell lineages from human tonsil specimens in order to examine the immunophenotypic alterations associated with KSHV infection. We describe IL-6 dependent maturation of naïve B lymphocytes in response to KSHV infection and determine that the Igλ monotypic bias of KSHV infection in vivo is due to viral induction of BCR revision. Infection of immunoglobulin κ (Igκ) naïve B cells induces expression of Igλ and isotypic inclusion, with eventual loss of Igκ. We show that this phenotypic shift occurs via re-induction of Rag-mediated V(D)J recombination. These data explain the selective presence of KSHV in Igλ B cells in vivo and provide the first evidence that a human pathogen can manipulate the molecular mechanisms responsible for immunoglobulin diversity. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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