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1. Short and long latency skin sensitizing antibody in passive cutaneous anaphylaxis in the monkey.

Author

Hutchcroft BJ, Moore EG, Orange RP, and Underdown BJ

Subjects
Absorption, Animals, Antibodies, Anti-Idiotypic, Chemical Fractionation, Chromatography, DEAE-Cellulose, Hot Temperature, Humans, Immunoglobulin E, Immunoglobulin G, Macaca mulatta, Mites, Sheep, Time Factors, Antibodies, Passive Cutaneous Anaphylaxis, Skin immunology
Abstract

In some allergic sera, 2-hr PCA responses can be due to IgE class antibody. In other sera where 2-hr PCA responses are not seen, removal of the IgG fracton allows expression of this 2-hr latency PCA response, suggesting an initial competition for binding sites between IgG and IgE, or that IgG can act as a blocking antibody, preventing antigen from reaching the cell-bound IgE.

Published
1980
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