1. Antiphospholipid syndrome in a patient with rheumatoid arthritis.
- Author
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O'Leary RE, Hsiao JL, and Worswick SD
- Subjects
- Adult, Antiphospholipid Syndrome immunology, Arthritis, Rheumatoid physiopathology, Female, Humans, Necrosis, Severity of Illness Index, Skin Ulcer immunology, Antibodies, Antiphospholipid immunology, Antiphospholipid Syndrome diagnosis, Arthritis, Rheumatoid immunology, Skin Ulcer diagnosis
- Abstract
Antiphospholipid syndrome (APS) is an autoimmune condition characterized by a thrombotic event and/or pregnancy morbidity in the presence of persistently elevated antiphospholipid (aPL) antibody titers, which are most prevalent in patients with systemic lupus erythematosus but also have been associated with other autoimmune, malignant, and infectious diseases. In contrast to the clear correlation between high aPL antibody titers and thrombotic events in patients with systemic lupus erythematosus, the pathogenic role of these autoantibodies in association with other diseases, such as rheumatoid arthritis (RA), is not as well defined. We report a case of APS manifesting as cutaneous ulceration and necrosis in a patient with severe RA.
- Published
- 2017