1. [Antiphospholipid antibodies and epilepsy in patients with systemic lupus erythematosus].
- Author
-
Formiga F, Moga I, Canet R, Pac M, Mitjavila F, and Pujol R
- Subjects
- Adult, Female, Humans, Male, Middle Aged, Retrospective Studies, Antibodies, Antiphospholipid blood, Epilepsy blood, Epilepsy complications, Lupus Erythematosus, Systemic blood, Lupus Erythematosus, Systemic complications
- Abstract
Objective: To verify the possible relationship between the presence of antiphospholipid antibodies (APLA) and the presence of epileptic seizures in patients with systemic lupus erythematosus (SLE)., Methods: A total of 168 patients with SLE were studied. Fifteen patients had antecedents of epilepsy which were non attributable to a cause other than SLE. Epilepsy was diagnosed on clinical and electroencephalographic grounds. Antibodies to cardiolipin (CLa) and lupus anticoagulant (LA) were measured., Results: Epileptic seizures were generalized in 13 and partial in two patients. The lupus anticoagulant was positive in 40% of patients with epilepsy compared to 32% in the control group; CLa IgG in 53.5% compared to 65.6%, and CLa IgM in 40% compared to 35.2%. Differences were never statistically significant. Neither when patients with moderate/high CLa levels were studied. Seven patients (40%) had some of the classical manifestations of antiphospholipid syndrome., Conclusions: No association was found between positive APLA and epilepsy in patients with SLE.
- Published
- 1996