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Abstract: In this study, highly sensitive immunochromatographic analyses (ICAs) of ciprofloxacin (CIP) are developed. CIP is an antibiotic of the fluoroquinolone group that is widely used in veterinary practice and contaminates agricultural products. The analyses are based on various techniques that introduce gold nanoparticles as markers. It has been shown that the schemes allow for the detection of CIP within 15 min with an instrumental detection limit of 10 pg/mL for both schemes and visual detection limits of 10 and 2 ng/mL for direct and indirect schemes, respectively. The developed systems have been tested to detect the antibiotic in milk samples. It has been shown that ICA can determine CIP in milk using a simple procedure of preliminary sample preparation with preservation of high analytical characteristics. [ABSTRACT FROM AUTHOR]