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Your search keyword '"Muraglia, Marilena"' showing total 3 results
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3 results on '"Muraglia, Marilena"'

1. Biological Evaluation of Hyperforin and Its Hydrogenated Analogue on Bacterial Growth and Biofilm Production

Author

Antonio Rosato, Ezio Bombardelli, Muraglia Marilena, Brigida Immacolata Pia Schiavone, Carlo Franchini, Simon Gibbons, Filomena Corbo, and Luisella Verotta

Subjects
Methicillin-Resistant Staphylococcus aureus, Staphylococcus aureus, medicine.drug_class, Antibiotics, Pharmaceutical Science, Microbial Sensitivity Tests, Phloroglucinol, Bacterial growth, Biology, Enterococcus faecalis, Analytical Chemistry, Microbiology, chemistry.chemical_compound, Drug Discovery, medicine, Pharmacology, Terpenes, Organic Chemistry, Biofilm, Hypericum perforatum, Antimicrobial, biology.organism_classification, Hyperforin, Complementary and alternative medicine, chemistry, Biofilms, Molecular Medicine, Hypericum
Abstract

Bacterial biofilms are organized communities of microorganisms, embedded in a self-produced matrix, growing on a biotic surface and resistant to many antimicrobial agents when associated with a medical device. These biofilms require the development of new strategies for the prevention and treatment of infectious disease, including the potential use of natural products. One interesting natural product example is Hypericum, a plant genus that contains species known to have antimicrobial properties. The major constituent of Hypericum perforatum is an unstable compound named hyperforin (1); for this reason it was not believed to play a significant role in the pharmacological effects. In this investigation a hydrogenated hyperforin analogue (2) was tested on several ATCC and clinical isolate strains, in their planktonic and biofilm form (Staphylococcus aureus, MRSA, and Enterococcus faecalis). Compound 2 was effective against planktonic and biofilm cultures, probably due to higher stability, showing the percentage of cells killed in the range from 45% to 52%. These results are noteworthy from the point of view of future development of these polyprenylated phloroglucinols as potential antibiotics.

Published
2013
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2. Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents.

Author

Giovine, Arianna, Muraglia, Marilena, Florio, Marco Antonio, Rosato, Antonio, Corbo, Filomena, Franchini, Carlo, Musio, Biagia, Degennaro, Leonardo, and Luisi, Renzo

Subjects
*ANTI-infective agents, *AZIRIDINES, *BORON compounds, *SUZUKI reaction, *PALLADIUM, *ANTIBIOTICS
Abstract

By using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl- or heteroarylboronic acids, new aziridines could be obtained. The cross-coupling reactions occurred without ring opening of the three membered ring. Preliminary results on the antimicrobial activity of the heterosubstituted biaryl compounds have been also included. [ABSTRACT FROM AUTHOR]

Published
2014
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3. Synthesis and Antimicrobial Evaluation of a New Series of N-1,3 -Benzothiazol-2-ylbenzamides.

Author

Armenise, Domenico, Carocci, Alessia, Catalano, Alessia, Muraglia, Marilena, Defrenza, Ivana, De Laurentis, Nicolino, Rosato, Antonio, Corbo, Filomena, and Franchini, Carlo

Subjects
ANTI-infective agents, BENZOTHIAZOLE, BENZAMIDE, FLUOROQUINOLONES, CHEMICAL synthesis, ANTIBIOTICS
Abstract

Enterococcus faecalis is a Gram-positive commensal inhabitant of the intestinal tract of humans, animals, and insects. However, it is also an opportunistic pathogen and has emerged as a leading cause of hospital-acquired extraintestinal infections. Fluoroquinolones have been frequently used to treat E. faecalis infections, and the emergence of fluoroquinolone-resistant E. faecalis strains has recently been reported in several countries. Thus, the identifications of new antibiotics specifically directed to E. faecalis may be envisaged. In this paper, a new series of N-1,3-benzothiazol-2-ylbenzamides have been designed, synthesized, and evaluated for their in vitro antimicrobial activities. Among the tested compounds, 3i was active against E. faecalis. [ABSTRACT FROM AUTHOR]

Published
2013
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