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1. Cefiderocol for the Treatment of Adult and Pediatric Patients With Cystic Fibrosis and Achromobacter xylosoxidans Infections.

Author

Warner, Nathaniel C, Bartelt, Luther A, Lachiewicz, Anne M, Tompkins, Kathleen M, Miller, Melissa B, Alby, Kevin, Jones, Melissa B, Carr, Amy L, Alexander, Jose, Gainey, Andrew B, Daniels, Robert, Burch, Anna-Kathryn, Brown, David E, Brownstein, Michael J, Cheema, Faiqa, Linder, Kristin E, Shields, Ryan K, Longworth, Sarah, and Duin, David van

Subjects
ANTIBIOTICS, RESEARCH, MEDICAL cooperation, RETROSPECTIVE studies, CYSTIC fibrosis, DISEASE relapse, GRAM-negative bacterial diseases
Abstract

Treatment options for Achromobacter xylosoxidans are limited. Eight cystic fibrosis patients with A. xylosoxidans were treated with 12 cefiderocol courses. Pretreatment in vitro resistance was seen in 3 of 8 cases. Clinical response occurred after 11 of 12 treatment courses. However, microbiologic relapse was observed after 11 of 12 treatment courses, notably without emergence of resistance. [ABSTRACT FROM AUTHOR]

Published
2021
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