1. Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump.
- Author
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Bolla, Jani Reddy, Su, Chih-Chia, Do, Sylvia V., Radhakrishnan, Abhijith, Kumar, Nitin, Long, Feng, Chou, Tsung-Han, Delmar, Jared A., Lei, Hsiang-Ting, Rajashankar, Kanagalaghatta R., Shafer, William M., and Yu, Edward W.
- Subjects
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CRYSTAL structure , *NEISSERIA gonorrhoeae , *MULTIDRUG resistance , *CELL membranes , *SEXUALLY transmitted diseases , *ANTIBIOTICS - Abstract
Neisseria gonorrhoeae is an obligate human pathogen and the causative agent of the sexually-transmitted disease gonorrhea. The control of this disease has been compromised by the increasing proportion of infections due to antibiotic-resistant strains, which are growing at an alarming rate. The MtrCDE tripartite multidrug efflux pump, belonging to the hydrophobic and amphiphilic efflux resistance-nodulation-cell division (HAE-RND) family, spans both the inner and outer membranes of N. gonorrhoeae and confers resistance to a variety of antibiotics and toxic compounds. We here report the crystal structure of the inner membrane MtrD multidrug efflux pump, which reveals a novel structural feature that is not found in other RND efflux pumps. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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