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Context:Stachys guyonianaNoë ex. Batt. andMentha aquaticaL. are two Algerian Lamiaceae used in folk medicine. Objective:To investigate their antioxidant, anticholinesterase and antibacterial activities. Material and methods:n-Butanol (BESG), ethyl acetate (EESG) and chloroform (CESG) extracts ofS. guyonianaand methanol (MEMA) and chloroform (CEMA) aerial part extracts ofM. aquaticaand methanol (MERMA) and acetone (AERMA) roots extracts ofM. aquaticawere evaluated for their antioxidant activity by the β-carotene-linoleic acid, DPPH•and ABTS•+ scavenging, CUPRAC and metal chelating assays. The anticholinesterase activity was tested against AChE and BChE. The antibacterial activity was assessed by MICs determination againstEscherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa,Salmonella heidelberg,Klebsiella pneumoniae, Enterobacter aerogenesandMorganella morganiistrains. Results:In the β-carotene test, the CESG (IC50: 2.3 ± 1.27 μg/mL) exhibited the highest activity. The BESG was the best scavenger of DPPH•(IC50: 2.91 ± 0.14 μg/mL). In the ABTS test, AERMA was the most active (IC50: 4.21 ± 0.28 μg/mL). However, with the CUPRAC, the BESG exhibited the best activity (A0.50: 0.15 ± 0.05 μg/mL) and was active in metal chelating assay with 48% inhibition at 100 μg/mL. The BESG was the best AChE inhibitor (IC50: 5.78 ± 0.01 μg/mL) however, the AERMA showed the highest BChE inhibitory activity (IC50: 19.23 ± 1.42 μg/mL). The tested extracts exhibited a good antibacterial activity. Conclusion:This study demonstrated good antioxidant, anticholinesterase and antibacterial potential ofS. guyonianaandM. aquatica,which fits in well with their use in folk medicine. [ABSTRACT FROM AUTHOR]