1. Anti-inflammatory and anti-osteoporotic lignans from Vitex negundo seeds.
- Author
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Zheng, Cheng-Jian, Zhang, Xiang-Wang, Han, Ting, Jiang, Yi-Ping, Tang, Jian-Yuan, Brömme, Dieter, and Qin, Lu-Ping
- Subjects
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OSTEOPOROSIS prevention , *PROTEIN metabolism , *ENZYME metabolism , *ALKALINE phosphatase , *ALTERNATIVE medicine , *ANIMAL experimentation , *ANTI-inflammatory agents , *BIOLOGICAL models , *PHYSICAL & theoretical chemistry , *DOSE-effect relationship in pharmacology , *LIGNANS , *MACROPHAGES , *MASS spectrometry , *MEDICINAL plants , *NITRIC oxide , *NUCLEAR magnetic resonance spectroscopy , *RATS , *SEEDS , *PLANT extracts , *DESCRIPTIVE statistics , *IN vitro studies , *PHARMACODYNAMICS - Abstract
Abstract: Chemical investigation of Vitex negundo seeds afforded four new lignans, including a phenylindene-type lignan, vitexdoin F (1), and three phenylnaphthalene-type lignans, vitexdoins G, H and I (2–4). Their structures were elucidated by detailed spectroscopic analyses on the basis of NMR, IR, and MS data. All compounds were evaluated for their anti-inflammatory and anti-osteoporotic activities, employing RAW264.7 macrophages, osteoblast-like UMR106 and osteoclastic cells, respectively. Compound 1 showed significant inhibition on the nitric oxide (NO) production (IC50 4.17μg/mL) due to its down-regulation of the inducible nitric oxide synthase (iNOS) protein expression in LPS-stimulated RAW264.7 cells, which also exhibited potent stimulatory effects on the proliferation and ALP (alkaline phosphatase) activity of UMR106 cells, and significantly up-regulated the OPG/RANKL protein ratio. [Copyright &y& Elsevier]
- Published
- 2014
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