1. New lignans, sesquiterpenes and other constituents from twigs and leaves of Rhododendron micranthum.
- Author
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Zhang Z, Yan H, Zhu Y, Zhang H, Chai L, Li L, Wang X, Liu Y, and Li Y
- Subjects
- Anti-Inflammatory Agents isolation & purification, Anti-Inflammatory Agents pharmacology, Cell Survival drug effects, China, Genes, Reporter, HEK293 Cells, Humans, Lignans isolation & purification, Lignans pharmacology, Magnetic Resonance Spectroscopy, Molecular Structure, NF-kappa B drug effects, Phytochemicals isolation & purification, Phytochemicals pharmacology, Plant Leaves chemistry, Plants, Medicinal, Sesquiterpenes isolation & purification, Sesquiterpenes pharmacology, Anti-Inflammatory Agents chemistry, Bronchitis, Chronic drug therapy, Lignans chemistry, Phytochemicals chemistry, Rhododendron chemistry, Sesquiterpenes chemistry
- Abstract
Rhododendron micranthum is used traditionally as a remedy for the treatment of chronic bronchitis in China. To clarify the chemical basis and provide a reference for the rational use of this medicinal plant, a phytochemical study was carried out on the twigs and leaves of R. micranthum, which afforded eight new compounds (1-8) and eight known compounds (9-16). Their structures were rigorously determined by comprehensive HRESIMS, NMR and electronic circular dichroism (ECD) analyses. The anti-inflammatory activities of these compounds were evaluated. Compounds 3, 13, and 14 suppressed the transcription of the NF-κB-dependent reporter gene in LPS-induced 293T/NF-κB-luc cells at 10 μM, while no effect on cell viability was observed., (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Published
- 2019
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