1. On the Alert for Cytokine Storm: Immunopathology in COVID-19.
- Author
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Henderson LA, Canna SW, Schulert GS, Volpi S, Lee PY, Kernan KF, Caricchio R, Mahmud S, Hazen MM, Halyabar O, Hoyt KJ, Han J, Grom AA, Gattorno M, Ravelli A, De Benedetti F, Behrens EM, Cron RQ, and Nigrovic PA
- Subjects
- Betacoronavirus, Biomarkers, COVID-19, Coronavirus Infections complications, Coronavirus Infections therapy, Cytokine Release Syndrome diagnosis, Early Medical Intervention, Humans, Pandemics, Pneumonia, Viral complications, Pneumonia, Viral therapy, SARS-CoV-2, Anti-Inflammatory Agents therapeutic use, Coronavirus Infections immunology, Cytokine Release Syndrome drug therapy, Cytokine Release Syndrome virology, Pneumonia, Viral immunology
- Abstract
Poor outcomes in COVID-19 correlate with clinical and laboratory features of cytokine storm syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy may prevent immunopathology and could help conserve limited health care resources. While studies are ongoing, extrapolating from clinical experience in cytokine storm syndromes may benefit the multidisciplinary teams caring for patients with severe COVID-19., (© 2020, American College of Rheumatology.)
- Published
- 2020
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