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1. Peroxisome Proliferator-Activated Receptor-α Activation as a Mechanism of Preventive Neuroprotection Induced by Chronic Fenofibrate Treatment.

Author

Deplanque, Dominique, Gele, Patrick, Petrault, Olivier, Six, Isabelle, Furman, Christophe, Bouly, Muriel, Nion, Stephane, Dupuis, Bernard, Leys, Didier, Fruchart, Jean-Charles, Cecchelli, Romeo, Staels, Bart, Duriez, Patrick, and Border, Regis

Subjects
PEROXISOMES, FENOFIBRATE, ANTIOXIDANTS, ANTI-inflammatory agents, BLOOD lipids, ENDOTHELIUM
Abstract

Proposes that a peroxisome proliferator-activated receptor activator, fenofibrate, protects against cerebral injury by anti-oxidant and anti-inflammatory mechanisms. Neuroprotective effect appears independently of any improvement in plasma lipids or glycemia; Cerebral blood flow measurement; Effect of chronic fenofibrate treatment on sensitivity to endothelial relaxation.

Published
2003
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