1. Pulmonary anti-inflammatory effects and spasmolytic properties of Costa Rican noni juice (Morinda citrifolia L.).
- Author
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Dussossoy E, Bichon F, Bony E, Portet K, Brat P, Vaillant F, Michel A, and Poucheret P
- Subjects
- Administration, Oral, Animals, Anti-Inflammatory Agents administration & dosage, Anti-Inflammatory Agents chemistry, Anti-Inflammatory Agents isolation & purification, Antioxidants pharmacology, Calcium Channel Blockers pharmacology, Calcium Signaling drug effects, Disease Models, Animal, Dose-Response Relationship, Drug, Fruit chemistry, In Vitro Techniques, Injections, Intraperitoneal, Jejunum metabolism, Lung drug effects, Lung metabolism, Muscle, Smooth metabolism, Nitric Oxide metabolism, Nitrites metabolism, Ovalbumin, Parasympatholytics administration & dosage, Parasympatholytics chemistry, Parasympatholytics isolation & purification, Phytotherapy, Plant Extracts administration & dosage, Plant Extracts chemistry, Plant Extracts isolation & purification, Plants, Medicinal, Pneumonia chemically induced, Pneumonia metabolism, Prednisolone pharmacology, Rats, Inbred BN, Anti-Inflammatory Agents pharmacology, Jejunum drug effects, Morinda chemistry, Muscle Contraction drug effects, Muscle, Smooth drug effects, Parasympatholytics pharmacology, Plant Extracts pharmacology, Pneumonia prevention & control
- Abstract
Ethnopharmacological Relevance: Morinda citrifolia L. (Noni) is a medicinal plant used in Polynesia for many properties such as anti-inflammatory, anti-diabetic and antineoplastic effects. Recent studies showed that noni juice have anti-oxidant and acute anti-inflammatory activities likely due to polyphenols, iridoids and vitamin C content. The present study was undertaken to evaluate chronic anti-inflammatory and spasmolytic effects of noni juice., Materials and Methods: Therefore, we evaluated the effect of oral or intraperitoneal administrations of noni juice in vivo on the lung inflammation in ovalbumin (OVA) sensitized Brown Norway rat (with prednisolone 10mg/kg intraperitoneously as reference compound) and the ex vivo effect of noni juice on BaCl
2 (calcium signal) or methacholine (cholinergic signal) induced spasms in jejunum segments., Results: We found that noni juice (intraperitoneously 2.17mL/kg and orally 4.55mL/kg) reduced the inflammation in OVA-sensitized Brown Norway rat with regard to the decreased number of inflammatory cells in lung (macrophages minus 20-26%, lymphocytes minus 58-34%, eosinophils minus 53-30%, neutrophils minus 70-28% respectively). Noni juice demonstrated a dose-dependent NO scavenging effect up to 8.1nmol of nitrites for 50µL of noni juice. In addition noni juice inhibited (up to 90%) calcium and cholinergic induced spasms on the jejunum segments model with a rightward shift of the concentration response curve., Conclusion: We describe for the first time that noni juice demonstrate (1) a chronic anti-inflammatory activity on sensitized lungs along with (2) a spasmolytic effect integrating a calcium channel blocker activity component., (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)- Published
- 2016
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