1. An indole diterpenoid isolated from the fungus Drechmeria sp. and its antimicrobial activity.
- Author
-
Liang JH, Huo XK, Cheng ZB, Sun CP, Zhao JC, Kang XH, Zhang TY, Chen ZJ, Yang TM, Wu YY, Deng XP, and Zhang YX
- Subjects
- Anti-Infective Agents chemistry, Anti-Infective Agents isolation & purification, Bacillus cereus drug effects, Candida albicans drug effects, Circular Dichroism, Diterpene Alkaloids chemistry, Diterpene Alkaloids isolation & purification, Indole Alkaloids chemistry, Indole Alkaloids isolation & purification, Magnetic Resonance Spectroscopy, Microbial Sensitivity Tests, Molecular Docking Simulation, Molecular Structure, Pseudomonas aeruginosa drug effects, Spectrometry, Mass, Electrospray Ionization, Staphylococcus aureus drug effects, Anti-Infective Agents pharmacology, Diterpene Alkaloids pharmacology, Hypocreales chemistry, Indole Alkaloids pharmacology
- Abstract
One new indole diterpenoid, drechmerin I ( 1 ), was isolated from the fermentation broth of Drechmeria sp. isolated from the root of Panax notoginseng . Its structure was elucidated based on 1 D and 2 D nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectrum (HRESIMS), and electronic circular dichroism (ECD) spectroscopic analyses as well as TD DFT calculations of ECD spectra. Drechmerin I ( 1 ) was assayed for its antimicrobial activity against Candida albicans , Staphylococcus aureus , Bacillus cereus , B. subtillis , Pseudomonas aeruginosa , and Klebsiella pneumonia , respectively. Drechmerin I ( 1 ) showed antimicrobial activities against B. subtillis with an MIC value of 200 μg/mL. The interaction of S. aureus peptide deformylase with drechmerin I ( 1 ) was investigated by molecular docking.
- Published
- 2019
- Full Text
- View/download PDF