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Your search keyword '"Restelli E"' showing total 3 results
Start Over Author "Restelli E" Topic anti-bacterial agents
3 results on '"Restelli E"'

1. Synthesis and antibacterial activity of derivatives of the glycopeptide antibiotic A-40926 and its aglycone.

Author

Hermann R, Ripamonti F, Romanò G, Restelli E, Ferrari P, Goldstein BP, Berti M, and Ciabatti R

Subjects
Animals, Anti-Bacterial Agents chemistry, Escherichia coli drug effects, Esters, Haemophilus influenzae drug effects, Mice, Microbial Sensitivity Tests, Molecular Structure, Structure-Activity Relationship, Teicoplanin analogs & derivatives, Anti-Bacterial Agents chemical synthesis, Anti-Bacterial Agents pharmacology, Glycopeptides, Gram-Negative Bacteria drug effects, Gram-Positive Cocci drug effects, Neisseria gonorrhoeae drug effects
Abstract

Starting from the antibiotic A-40926 and the aglycone of A-40926 a series of compounds were prepared by modifying the free functionalities. Their antimicrobial activity was determined, particularly against Neisseria gonorrhoeae, against which A-40926, unlike other natural glycopeptides, is active. Improved in vivo activity was displayed by the monomethyl ester of A-40926 esterified at the carboxyl group of the N-acylamino-glucuronyl moiety.

Published
1996
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2. Components of the GE2270 complex produced by Planobispora rosea ATCC 53773.

Author

Selva E, Ferrari P, Kurz M, Tavecchia P, Colombo L, Stella S, Restelli E, Goldstein BP, Ripamonti F, and Denaro M

Subjects
Actinomycetales metabolism, Anti-Bacterial Agents isolation & purification, Anti-Bacterial Agents pharmacology, Chromatography, High Pressure Liquid, Fermentation, Microbial Sensitivity Tests, Molecular Structure, Peptides, Cyclic, Spectrometry, Mass, Fast Atom Bombardment, Structure-Activity Relationship, Thiazoles pharmacology, Anti-Bacterial Agents chemistry, Thiazoles chemistry
Published
1995
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3. Isolation, structure determination and biological activity of A-16686 factors A' 1, A' 2 and A' 3 glycolipodepsipeptide antibiotics.

Author

Gastaldo L, Ciabatti R, Assi F, Restelli E, Kettenring JK, Zerilli LF, Romanò G, Denaro M, and Cavalleri B

Subjects
Actinomycetales metabolism, Amino Acid Sequence, Anti-Bacterial Agents isolation & purification, Anti-Bacterial Agents pharmacology, Biotransformation, Microbial Sensitivity Tests, Molecular Sequence Data, Molecular Structure, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents metabolism, Depsipeptides, Peptides, Cyclic
Abstract

When Actinoplanes strain ATCC 33076, the producer of A-16686 A1, A2 and A3 complex, is fermented in a suitable medium three additional factors, designated A' 1, A' 2 and A' 3 are produced. These were isolated and characterized, and were shown to differ from the parent components of the original complex by lacking one mannose unit. Bioconversion of A factors into A' factors was achieved by incubation with the mycelium of Actinoplanes ATCC 33076. Factor A' 2 has better antibacterial activity than A2 against some bacteria.

Published
1992
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