Search

Currently, Nano-materials have been explored for their abundant biomedical applications. In the present study the green synthesized (SC-AgNPs) by root extract of Smilax Chenensis have been characterized by UV-visible spectroscopy revealed SPR peak at 432 nm and FT-IR data reveals that the bioactive components of root extract have been actively involved in the reduction and stabilization of SC-AgNPs. TEM and AFM results revealed that SC-AgNPs were roughly spherical in shape. Further, the particle size of SC-AgNPs was also carried out by Dynamic Light Scattering method by aqueous colloidal solution and the results reveals that the SC-AgNPs are poly-dispersed in nature with an average size 45.6 nm with a Z average of 39.5 nm. The stability of colloidal SC-AgNPs was further confirmed by negative zeta potential value of - 21.0 mV. The SC-AgNPs showed good antibacterial activity against both gram -ve and gram + ve bacteria, whereas, SC-AgNPs coupled with antibiotic reveals excellent and enhanced antibacterial activity. The gram -ve E.coli and gram + ve S.aureus revealed highest zone of inhibition when compared to other two bacterial species. So, SC-AgNPs coupled with antibiotics can be excellent alternative to treat antibiotic resistant bacteria. The SC-AgNPs also reveals excellent antioxidant activity among them DPPH method revealed superior activity with an IC 50 value76.22. The SC-AgNPs also reveals superior anticancer activity against MDA-MB-231 with IC 50 value of 33.98 µg/mL and photo-catalytic activity the optical density of reduced from 1.861 to 0.135 OD within 30 min. The green SC-AgNPs detected to have multiple therapeutic applications., Competing Interests: Declarations. Competing interests: The authors declare no competing interests., (© 2024. The Author(s).)

Nanoparticles have been used to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. The plant extracts are eco-friendly, economical and cost effective for synthesis of large scale of nanoparticles. In this paper we represent the synthesis of silver nanoparticles (AgNPs) from room dried leaves of Vinca rosea. The AgNPs were characterized by UV-vis spectroscopy. The AgNPs are crystalline in nature, were determined from scanning electron microscopy (SEM) coupled with energy dispersive X-ray (EDX), X-ray diffraction patterns (XRD), and also the size of the NPs was calculated by using Hariba Nanoparticle analyzer and the stability was calculated by using the Zetapotential. The nanoparticles obtained from leaf extracts were of size 27±2 and 30±2 respectively and Zetapotential of AgNPs was found to be -63.1 mV, so it indicates the dispersion and stability. The synthesized AgNPs have very good antimicrobial activity., (Copyright © 2013 Elsevier B.V. All rights reserved.)