1. Comparison of the characteristics, morbidity and mortality of COVID-19 between first and second/third wave in a hospital setting in Lombardy: a retrospective cohort study
- Author
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Francesca Leidi, Gianluca Edoardo Mario Boari, Ottavio Scarano, Benedetta Mangili, Giulia Gorla, Andrea Corbani, Beatrice Accordini, Federico Napoli, Chiara Ghidelli, Giulia Archenti, Daniele Turini, Michele Saottini, Vittoria Guarinoni, Giulia Ferrari-Toninelli, Francesca Manzoni, Silvia Bonetti, Giulia Chiarini, Paolo Malerba, Federico Braglia-Orlandini, Gianluca Bianco, Cristina Faustini, Claudia Agabiti-Rosei, Carolina De Ciuceis, and Damiano Rizzoni
- Subjects
Male ,Angiotensins ,Heparin ,SARS-CoV-2 ,COVID-19 ,Hospitals ,Anti-Bacterial Agents ,Oxygen ,C-Reactive Protein ,Emergency Medicine ,Internal Medicine ,Humans ,Female ,Hospital Mortality ,Morbidity ,Procalcitonin ,Antihypertensive Agents ,Retrospective Studies - Abstract
Coronavirus disease 2019 (COVID-19) represents a major health problem in terms of deaths and long-term sequelae. We conducted a retrospective cohort study at Montichiari Hospital (Brescia, Italy) to better understand the determinants of outcome in two different COVID-19 outbreaks. A total of 634 unvaccinated patients admitted from local emergency room to the Internal Medicine ward with a confirmed diagnosis of SARS-CoV-2 infection and a moderate-to-severe COVID-19 were included in the study. A group of 260 consecutive patients during SARS-CoV-2 first wave (from February to May 2020) and 374 consecutive patients during SARS-CoV-2 2nd/3rd wave (from October 2020 to May 2021) were considered. Demographic data were not significantly different between waves, except a lower prevalence of female sex during first wave. Mortality was significantly higher during the 1st wave than in the following periods (24.2% vs. 11%; p p p
- Published
- 2022